Welcome to Sperry Research Group.
Our primary research focus is centered around exploring and advancing knowledge in [your research area]. Our interdisciplinary team works collaboratively to push the boundaries of [specific field or fields], aiming to contribute impactful discoveries and innovative solutions.
Below, you can explore our key research areas by clicking on the tabs
C-H Functionalization
Our research in Organic Chemistry focuses on the synthesis of natural products as a foundation for developing innovative methods. We place particular emphasis on compounds with unprecedented architecture, biomimetic synthesis, and the development of novel reactions. Through these studies, we aim to advance the field by creating new pathways and techniques that can be applied to complex molecular structures.
Therapeutics for Unmet Medical Needs
Our group is committed to developing novel therapeutics to address critical areas of unmet medical need. Our research spans several key areas:
- Isocitrate Lyase (ICL) Inhibitors for Tuberculosis Treatment:
We focus on the synthesis and biophysical analysis of ICL inhibitors aimed at treating latent tuberculosis. This work is conducted in collaboration with Dr. Ivan Leung and Dr. Ghader Bashiri at the University of Auckland. - Natural Products for Neuropsychiatric Disorders:
We investigate natural products and their analogues as potential treatments for neuropsychiatric disorders, including depression, schizophrenia, psychosis, OCD, and anxiety. - Targeting the PSA-NCAM Complex for Brain Cancer Therapy:
In collaboration with A/P Maurice Curtis at the Centre for Brain Research, we are pioneering new therapeutic strategies targeting the PSA-NCAM complex, with a focus on treating brain cancers such as glioma and glioblastoma.
Our group strives to advance sustainable synthesis and green chemistry methods, focusing on environmentally friendly approaches to chemical production. Our key areas of study include:
- Biorenewable Platform Chemicals:
We explore the use of biorenewable platform chemicals in the synthesis of fine and commodity chemicals. This research is conducted in collaboration with A/P Shinji Kudo (Kyushu University, Japan), A/P Ning Yan (National University of Singapore), and Prof. Xianhei Zeng (Xiamen University). - Electrochemical Synthesis:
We develop electrochemical methods to achieve sustainable chemical transformations, minimizing energy consumption and waste. - Mechanochemical Synthesis and Pollutant Degradation:
Our work includes the use of mechanochemical processes for both the synthesis of chemicals and the degradation of environmental pollutants. We aim to promote solventless reactions. - Valorization of Lignin:
We focus on converting lignin into valuable alkanes that can be used as bio-based solvents, transportation fuels, and other applications. - Green Solvents and Reagents:
We are committed to discovering new and optimizing existing methods to utilise greener solvents and reagents to reduce the environmental impact of chemical processes and the contribute to advancing the working conditions, health, safety and wellbeing of our researchers.